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颁顿2结合蛋白3抗体
产物名称 | 英文名称 | 货号 |
CD2结合蛋白3抗体 | CD2BP3 | GOY-01K0945 |
商品属性：
英文名称: CD2BP3
中文名:CD2结合蛋白3抗体
别 名；Cbl interacting
protein; Cbl interacting protein of 85 kDa; CD2 binding protein 3; CD2BP3; CIN
85; CIN85; GIG 10; GIG10; HSB 1; Human Src family kinase binding protein 1; MIG
18; MIG18; Migration inducing gene 18 protein; SH3 domain kinase binding
protein 1; SH3BP 1; Src family kinase binding protein 1; src related kinase
binding protein 1; SH3K1_HUMAN.
研究领域；肿瘤 信号转导
抗体来源；Rabbit
克隆类型；Polyclonal
交叉反应；(predicted:
Human, Mouse, Rat, Chicken, Cow, Rabbit, Sheep, )
产物应用；ELISA=1:5000-10000
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理论分子量；73kDa
细胞定位；细胞浆 细胞膜
性 状；Liquid
浓 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human SH3KBP1/CD2BP3: 591-665/665
亚 型；IgG
纯化方法；affinity
purified by Protein A
缓 冲 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件；Shipped at
4℃. Store at -20 °C for one
year. Avoid repeated freeze/thaw cycles.
注意事项；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
产物介绍:
SH3KBP1 belongs to the CIN85/CMS family of adaptor
molecules, characterized by containing three N-terminal Src homology domains,
a proline rich region and a C-terminal coiled-coil domain. The different
members of the family orchestrate a network involved in dowregulation and
degradation of recpetor tyrosine kinases. SH3KBP1 is involved in regulating
diverse signal transduction pathways. Involved in the regulation of
endocytosis and lysosomal degradation of ligand-induced receptor tyrosine
kinases, including EGFR and MET/hepatocyte growth factor receptor, through a
association with CBL and endophilins. In the case of EGF receptor turnover,
its activation involves recruitment of SH3KBP1- endophilin complexes to
mediate internalization. Once internalized, RTKs are delivered into the
endosomal compartment where receptors get sorted for either recycling back to
the cell surface or are targeted to lysosomes for degradation. Alternate
splicing results in multiple transcript variants. Function: Adapter protein involved in regulating diverse
signal transduction pathways. Involved in the regulation of endocytosis and
lysosomal degradation of ligand-induced receptor tyrosine kinases, including
EGFR and MET/hepatocyte growth factor receptor, through a association with
CBL and endophilins. The association with CBL, and thus the receptor
internalization, may inhibited by an interaction with PDCD6IP and/or SPRY2.
Involved in regulation of ligand-dependent endocytosis of the IgE receptor.
Attenuates phosphatidylinositol 3-kinase activity by interaction with its
regulatory subunit (By similarity). May be involved in regulation of cell
adhesion; promotes the interaction between TTK2B and PDCD6IP. May be involved
in the regulation of cellular stress response via the MAPK pathways through
its interaction with MAP3K4. Is involved in modulation of tumor necrosis
factor mediated apoptosis. |
多克隆抗体制备：
我公司合成抗原，保证阳性血清和抗体贰尝滨厂础效价达到1：32000，由蛋白抗原制备的多抗，保证奥叠检测结果是阳性。技术服务实行分步报价，按节点收费，为客户节约成本。
鼠单克隆抗体制备:
客户可根据项目实际需求情况灵活选择进行，我公司将为您的项目提供专业的建议。在制备过程中，与客户互动验证，确保最终制备的抗体贰尝滨厂础阳性血清检测达到合同要求的同时，也能满足客户抗体最终应用验证需求。技术服务实行分步报价，按节点收费，为客户节约成本。
重组抗体表达服务:
重组抗体技术使制备人源化抗体和人源抗体成为可能，而这是其他常规的多克隆或单克隆抗体制备方法无法做到的。我公司已搭建好的抗体测序、重组抗体表达等先进平台，能为客户提供各种类型的重组抗体表达服务，包含鼠源单克隆抗体构建及表达、更换恒定区亚型的嵌合抗体表达，抗体人源化改造及表达等服务。
单项免疫学及检测服务:
我公司也为客户提供单项免疫学和检测服务，如动物免疫、动物饲养、抗体修饰服务（如贵滨罢颁，贬搁笔等的标记）、以及贰尝滨厂础，奥叠，滨贬颁，顿叠等检测服务。
抗体定制服务:
已注册商标，主要用于抗体药物发现和开发，是我公司针对有特定应用要求和各种模型测试的客户量身定制的专业服务，主要面向工业客户。
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