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环磷酸鸟苷门控通道蛋白CNG4抗体
产物名称 | 英文名称 | 货号 |
环磷酸鸟苷门控通道蛋白CNG4抗体 | CNGB1 | GOY-01K2031 |
商品属性：
英文名称: CNGB1
中文名:环磷酸鸟苷门控通道蛋白CNG4抗体
别 名；CNG4; GAR1; GARP;
RP45; CNCG2; CNCG4; GARP2; RCNC2; RCNCb; CNCG3L; CNGB1B; RCNCbeta; CNG-4;
cyclic nucleotide gated channel subunit beta 1; Cyclic nucleotide-gated cation
channel beta-1; Cyclic nucleotide-gated cation channel 4; CNG channel 4; Cyclic
nucleotide-gated cation channel gamma; Cyclic nucleotide-gated cation channel
modulatory subunit; CNG channel beta-1; Glutamic acid-rich protein;
CNGB1_HUMAN.
研究领域；神经生物学 通道蛋白 细胞膜受体 G蛋白偶联受体 G蛋白信号
抗体来源；Rabbit
克隆类型；Polyclonal
交叉反应；(predicted:
Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, Sheep, )
产物应用；ELISA=1:5000-10000
IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理论分子量；140kDa
细胞定位；细胞膜
性 状；Liquid
浓 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human CNGB1: 856-960/1251
<Extracellular>
亚 型；IgG
纯化方法；affinity
purified by Protein A
缓 冲 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
注意事项；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
产物介绍:
Cyclic nucleotide-gated (CNG) cation channels are
heteromeric complexes made up of principal alpha and modulatory beta subunits
(1,2). The alpha subunits consist of CNG1-3 and form functional cation
channels by themselves (1,2). The beta subunits consist of CNG4-6 and, unlike
the alpha subunits, do not form functional channels, but rather modify the
properties of channels (1,2). CNG channels are essential components of
olfactory and visual transduction (1,2). In olfactory neurons, CNG2, CNG4.3
and CNG5 form Ca2+ permeable channels, which open and depolarize the cell in
response to cAMP (1-3). In rod photoreceptors, CNG1 and CNG4.1 combine to
form Ca ion permeable channels, which give rise to a current in response to
cGMP (1-3). CNG3 and CNG6 are expressed in cone receptors and may combine to
form a native cGMP-activated channel (2,3). CNG channels have been implicated
in other areas (4-6). CNG1 is also expressed in medium-sized and small-sized
arteries, suggesting a role for CNG in the regulation of arterial blood pressure
and of blood supply to different regions (4). CNG1, CNG4.1 and CNG4.2 have
been detected in the rat pineal gland (5). CNG2, CNG4.3 and CNG5 are present
in GT1 cell lines and may play a role in the secretion of
gonadotropin-releasing hormone (6). GARP is a subunit of cyclic nucleotide-gated (CNG)
channels, nonselective cation channels, which play important roles in both
visual and olfactory signal transduction. When associated with CNGA1, it is
involved in the regulation of ion flow into the rod photoreceptor outer
segment (ROS), in response to light-induced alteration of the levels of
intracellular cGMP. Defects in GARP are the cause of retinitis pigmentosa
type 45 (RP45). RP leads to degeneration of retinal photoreceptor cells.
Patients typically have night vision blindness and loss of midperipheral
visual field. As their condition progresses, they lose their far peripheral
visual field and eventually central vision as well. |
多克隆抗体制备：
我公司合成抗原，保证阳性血清和抗体贰尝滨厂础效价达到1：32000，由蛋白抗原制备的多抗，保证奥叠检测结果是阳性。技术服务实行分步报价，按节点收费，为客户节约成本。
鼠单克隆抗体制备:
客户可根据项目实际需求情况灵活选择进行，我公司将为您的项目提供专业的建议。在制备过程中，与客户互动验证，确保最终制备的抗体贰尝滨厂础阳性血清检测达到合同要求的同时，也能满足客户抗体最终应用验证需求。技术服务实行分步报价，按节点收费，为客户节约成本。
重组抗体表达服务:
重组抗体技术使制备人源化抗体和人源抗体成为可能，而这是其他常规的多克隆或单克隆抗体制备方法无法做到的。我公司已搭建好的抗体测序、重组抗体表达等先进平台，能为客户提供各种类型的重组抗体表达服务，包含鼠源单克隆抗体构建及表达、更换恒定区亚型的嵌合抗体表达，抗体人源化改造及表达等服务。
单项免疫学及检测服务:
我公司也为客户提供单项免疫学和检测服务，如动物免疫、动物饲养、抗体修饰服务（如贵滨罢颁，贬搁笔等的标记）、以及贰尝滨厂础，奥叠，滨贬颁，顿叠等检测服务。
抗体定制服务:
已注册商标，主要用于抗体药物发现和开发，是我公司针对有特定应用要求和各种模型测试的客户量身定制的专业服务，主要面向工业客户。
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