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β4整合素结合蛋白抗体
产物名称 | 英文名称 | 货号 |
β4整合素结合蛋白抗体 | eIF6 | GOY-01K1428 |
商品属性：
英文名称: eIF6
中文名:β4整合素结合蛋白抗体
别 名；b(2)gcn; B(2)GCN
homolog; B4 integrin interactor; Binding protein of beta-4 integrin; CAB;
eIF-6; EIF3A; Eukaryotic translation initiation factor 3A; Eukaryotic
translation initiation factor 6; IF6_HUMAN; ITGB4BP; OK/SW-cl.27; p27 beta 4
integrin binding protein; p27(BBP); p27BBP; RP4-614O4.1.
研究领域；肿瘤 免疫学 信号转导 转录调节因子
抗体来源；Rabbit
克隆类型；Polyclonal
交叉反应；(predicted:
Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, Sheep, )
产物应用；ELISA=1:5000-10000
IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理论分子量；27kDa
细胞定位；细胞核 细胞浆
性 状；Liquid
浓 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human ITGB4BP: 141-245/245
亚 型；IgG
纯化方法；affinity
purified by Protein A
缓 冲 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
注意事项；This product
as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
产物介绍:
Hemidesmosomes are structures which link the basal
lamina to the intermediate filament cytoskeleton. An important functional
component of hemidesmosomes is the integrin beta-4 subunit (ITGB4), a protein
containing two fibronectin type III domains. The protein encoded by Intergrin
beta 4 binding protein binds to the fibronectin type III domains of ITGB4 and
may help link ITGB4 to the intermediate filament cytoskeleton. The encoded
protein, which is insoluble and found both in the nucleus and in the
cytoplasm, can function as a translation initiation factor and prevent the
association of the 40S and 60S ribosomal subunits. Multiple transcript
variants encoding several different isoforms have been found for this gene. Binds to the 60S ribosomal subunit and prevents
its association with the 40S ribosomal subunit to form the 80S initiation
complex in the cytoplasm. May behave as a stimulatory translation initiation
factor downstream insulin/growth factors. Is also involved in ribosome
biogenesis. Associates with pre-60S subunits in the nucleus and is involved
in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and
nuclear relocalization is promoted by a RACK1 (GNB2L1)-dependent protein
kinase C activity. |
多克隆抗体制备：
我公司合成抗原，保证阳性血清和抗体贰尝滨厂础效价达到1：32000，由蛋白抗原制备的多抗，保证奥叠检测结果是阳性。技术服务实行分步报价，按节点收费，为客户节约成本。
鼠单克隆抗体制备:
客户可根据项目实际需求情况灵活选择进行，我公司将为您的项目提供专业的建议。在制备过程中，与客户互动验证，确保最终制备的抗体贰尝滨厂础阳性血清检测达到合同要求的同时，也能满足客户抗体最终应用验证需求。技术服务实行分步报价，按节点收费，为客户节约成本。
重组抗体表达服务:
重组抗体技术使制备人源化抗体和人源抗体成为可能，而这是其他常规的多克隆或单克隆抗体制备方法无法做到的。我公司已搭建好的抗体测序、重组抗体表达等先进平台，能为客户提供各种类型的重组抗体表达服务，包含鼠源单克隆抗体构建及表达、更换恒定区亚型的嵌合抗体表达，抗体人源化改造及表达等服务。
单项免疫学及检测服务:
我公司也为客户提供单项免疫学和检测服务，如动物免疫、动物饲养、抗体修饰服务（如贵滨罢颁，贬搁笔等的标记）、以及贰尝滨厂础，奥叠，滨贬颁，顿叠等检测服务。
抗体定制服务:
已注册商标，主要用于抗体药物发现和开发，是我公司针对有特定应用要求和各种模型测试的客户量身定制的专业服务，主要面向工业客户。
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