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跨膜通道蛋白8抗体
产物名称 | 英文名称 | 货号 |
跨膜通道蛋白8抗体 | EVER2 | GOY-01K0700 |
商品属性：
英文名称: EVER2
中文名:跨膜通道蛋白8抗体
别 名；epidermodysplasia
verruciformis 2; Epidermodysplasia verruciformis protein 2; EV2; EVIN2;
FLJ40668; FLJ43684; MGC102701; MGC40121; TMC8; Transmembrane channel like
protein 8; TMC8_HUMAN.
研究领域；肿瘤 细胞生物 跨膜蛋白
抗体来源；Rabbit
克隆类型；Polyclonal
交叉反应；(predicted:
Human, Mouse, Rat, Cow, Horse, Sheep, )
产物应用；WB=1:500-2000
ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理论分子量；82kDa
细胞定位；细胞浆 细胞膜
性 状；Liquid
浓 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human EVER2/TMC8: 301-400/726
亚 型；IgG
纯化方法；affinity
purified by Protein A
缓 冲 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
注意事项；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
产物介绍:
Transmembrane channel-like protein 8 (TMC8), also
known as Epidermodysplasia verruciformis protein 2 (EVER2), is a 726 amino
acid member of the TMC family of proteins. Localized to the endoplasmic
reticulum membrane, TMC8 is thought to form a transmembrane channel-like
protein with eight predicted transmembrane domains and three leucine zipper
motifs. Mutations in the genes encoding TMC8 and TMC6, another member of the
TMC family, have been shown to cause epidermodysplasia verruciformis (EV), an
autosomal recessive dermatosis characterized by abnormal susceptibility to
human papillomaviruses (HPVs) and a high rate of progression to squamous cell
carcinoma on sun-exposed skin. Infection by HPVs lead to persistent wart-like
or macular lesions. TMC8 is expressed in placenta, prostate and testis, and
three named isoforms exist as a result of alternative splicing events. Epidermodysplasia verruciformis (EV) is an
autosomal recessive genodermatosis associated with a high risk of skin
cancers resulting from a high susceptibility to infection by specific human
papillomaviruses. Mutations in two homologous genes EVER1 and EVER2 cause the
majority of EV cases. These two proteins form a complex and interact with the
zinc transporter ZnT-1 in the endoplasmic reticulum. Cells lacking EVER2
accumulated higher levels of zinc in the nucleolus and nucleus compare to
those cells with and intact EVER2 gene, indicating that one role of EVER2 is
to regulate the intracellular distribution of zinc. At least two isoforms of
EVER2 are known to exist. |
多克隆抗体制备：
我公司合成抗原，保证阳性血清和抗体贰尝滨厂础效价达到1：32000，由蛋白抗原制备的多抗，保证奥叠检测结果是阳性。技术服务实行分步报价，按节点收费，为客户节约成本。
鼠单克隆抗体制备:
客户可根据项目实际需求情况灵活选择进行，我公司将为您的项目提供专业的建议。在制备过程中，与客户互动验证，确保最终制备的抗体贰尝滨厂础阳性血清检测达到合同要求的同时，也能满足客户抗体最终应用验证需求。技术服务实行分步报价，按节点收费，为客户节约成本。
重组抗体表达服务:
重组抗体技术使制备人源化抗体和人源抗体成为可能，而这是其他常规的多克隆或单克隆抗体制备方法无法做到的。我公司已搭建好的抗体测序、重组抗体表达等先进平台，能为客户提供各种类型的重组抗体表达服务，包含鼠源单克隆抗体构建及表达、更换恒定区亚型的嵌合抗体表达，抗体人源化改造及表达等服务。
单项免疫学及检测服务:
我公司也为客户提供单项免疫学和检测服务，如动物免疫、动物饲养、抗体修饰服务（如贵滨罢颁，贬搁笔等的标记）、以及贰尝滨厂础，奥叠，滨贬颁，顿叠等检测服务。
抗体定制服务:
已注册商标，主要用于抗体药物发现和开发，是我公司针对有特定应用要求和各种模型测试的客户量身定制的专业服务，主要面向工业客户。
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