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γ-衔接蛋白相关蛋白1抗体
产物名称 | 英文名称 | 货号 |
γ-衔接蛋白相关蛋白1抗体 | GGA1 | GOY-01K0682 |
商品属性：
英文名称: GGA1
中文名:γ-衔接蛋白相关蛋白1抗体
别 名；4930406E12Rik;
ADP ribosylation factor binding protein 1; ADP ribosylation factor binding
protein GGA1; ADP-ribosylation factor-binding protein GGA1; ARF binding protein
1; ARF-binding protein 1; Gamma adaptin related protein 1; gamma
ear-containing; Gamma-adaptin-related protein 1; GGA 1; GGA1; GGA1 protein;
GGA1_HUMAN; Golgi associated gamma adaptin ear containing ARF; Golgi associated
gamma adaptin ear containing ARF binding protein 1; Golgi localized gamma ear
containing ARF binding protein 1; Golgi-localized; OTTHUMP00000028975;
OTTHUMP00000042200.
研究领域；细胞生物 信号转导 转运蛋白
抗体来源；Rabbit
克隆类型；Polyclonal
交叉反应；(predicted:
Human, Mouse, Rat, Dog, Pig, Cow, Sheep, )
产物应用；ELISA=1:5000-10000
IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理论分子量；70kDa
细胞定位；细胞浆 细胞膜
性 状；Liquid
浓 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human GGA1: 51-150/639
亚 型；IgG
纯化方法；affinity
purified by Protein A
缓 冲 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
注意事项；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
产物介绍:
The GGA family of proteins (Golgi-localized,
ARF-binding proteins) are ubiquitous coat proteins that facilitate the
trafficking of soluble proteins from the trans-Golgi network (TGN) to
endosomes/lysosomes by means of interactions with TGN-sorting receptors, ARF
(ADP-ribosylation factor), and clathrin (1?). Members of the GGA family,
GGA1,GGA2 (also known as VEAR) and GGA3, are multidomain proteins that bind
mannose 6-phosphate receptors (MPRs) (1,2,4). GGAs have modular structures
with an N-terminal VHS (VPS-27, Hrs, and STAM) domain followed by a GAT (GGA
and TOM1) domain, a connecting hinge segment, and a C-terminal GAE (?adaptin
ear) domain (5). The amino-terminal VHS domains of GGAs form complexes with
the cytoplasmic domains of sorting receptors by recognizing acidic-cluster
di-leucine (ACLL) sequences (3). GGA1 and GGA2 do not associate with each
other, but they do colocalize on perinuclear membranes (2). The cytosolic
domain of memapsin 2, but not that of memapsin 1, binds the VHS domains of GGA1
and GGA2 (6). The human GGA1 gene maps to chromosome 22 and encodes a protein
that shares 45% sequence identity with GGA2 and GGA3 (1). Plays a role in protein sorting and trafficking
between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent
recruitment of clathrin to the TGN and binds ubiquitinated proteins and
membrane cargo molecules with a cytosolic acidic cluster-dileucine (AC-LL)
motif. |
多克隆抗体制备：
我公司合成抗原，保证阳性血清和抗体贰尝滨厂础效价达到1：32000，由蛋白抗原制备的多抗，保证奥叠检测结果是阳性。技术服务实行分步报价，按节点收费，为客户节约成本。
鼠单克隆抗体制备:
客户可根据项目实际需求情况灵活选择进行，我公司将为您的项目提供专业的建议。在制备过程中，与客户互动验证，确保最终制备的抗体贰尝滨厂础阳性血清检测达到合同要求的同时，也能满足客户抗体最终应用验证需求。技术服务实行分步报价，按节点收费，为客户节约成本。
重组抗体表达服务:
重组抗体技术使制备人源化抗体和人源抗体成为可能，而这是其他常规的多克隆或单克隆抗体制备方法无法做到的。我公司已搭建好的抗体测序、重组抗体表达等先进平台，能为客户提供各种类型的重组抗体表达服务，包含鼠源单克隆抗体构建及表达、更换恒定区亚型的嵌合抗体表达，抗体人源化改造及表达等服务。
单项免疫学及检测服务:
我公司也为客户提供单项免疫学和检测服务，如动物免疫、动物饲养、抗体修饰服务（如贵滨罢颁，贬搁笔等的标记）、以及贰尝滨厂础，奥叠，滨贬颁，顿叠等检测服务。
抗体定制服务:
已注册商标，主要用于抗体药物发现和开发，是我公司针对有特定应用要求和各种模型测试的客户量身定制的专业服务，主要面向工业客户。
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