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铁调节蛋白25抗体
产物名称 | 英文名称 | 货号 |
铁调节蛋白25抗体 | Hepcidin-25 | GOY-01K1719 |
商品属性：
英文名称: Hepcidin-25
中文名:铁调节蛋白25抗体
别 名；Hamp; HEPC;
HEPC_HUMAN; Hepc20; Hepc25; HEPCIDIN; Hepcidin; Hepcidin 20; Hepcidin 25;
Hepcidin antimicrobial peptide; Hepcidin-20; Hepcidin25; HFE2; HFE2B; LEAP 1;
LEAP-1; LEAP1; Liver expressed antimicrobial peptide; Liver-expressed
antimicrobial peptide 1; PLTR; Putative liver tumor regressor. 铁调素; 海帕西啶; 肝脏抗菌多肽; 抗菌肽; 铁调节蛋白;
抗体来源；Rabbit
克隆类型；Polyclonal
交叉反应； Human,
产物应用；ELISA=1:5000-10000
IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理论分子量；2/3kDa
细胞定位；分泌型蛋白
性 状；Liquid
浓 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human Hepcidin-25: 60-84/84
亚 型；IgG
纯化方法；affinity
purified by Protein A
缓 冲 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
注意事项；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
产物介绍:
The product encoded by this gene is involved in
the maintenance of iron homeostasis, and it is necessary for the regulation
of iron storage in macrophages, and for intestinal iron absorption. The
preproprotein is post-translationally cleaved into mature peptides of 20, 22
and 25 amino acids, and these active peptides are rich in cysteines, which
form intramolecular bonds that stabilize their beta-sheet structures. These
peptides exhibit antimicrobial activity. Mutations in this gene cause
hemochromatosis type 2B, also known as juvenile hemochromatosis, a disease
caused by severe iron overload that results in cardiomyopathy, cirrhosis, and
endocrine failure. [provided by RefSeq, Jul 2008]. Seems to act as a signaling molecule involved in
the maintenance of iron homeostasis. Seems to be required in conjunction with
HFE to regulate both intestinal iron absorption and iron storage in
macrophages. Has strong antimicrobial activity against E.coli ML35P N.cinerea
and weaker against S.epidermidis, S.aureus and group b streptococcus bacteria.
Active against the fungus C.albicans. No activity against P.aeruginosa. Involvement in disease;Defects in HAMP are the
cause of hemochromatosis type 2B (HFE2B); also known as juvenile
hemochromatosis (JH). HFE2B is a disorder of iron metabolism with excess
deposition of iron in the tissues, bronze skin pigmentation, hepatic
cirrhosis, arthropathy and diabetes. The most common symptoms of
hemochromatosis type 2 at presentation are hypogonadism and cardiomyopathy. |
多克隆抗体制备：
我公司合成抗原，保证阳性血清和抗体贰尝滨厂础效价达到1：32000，由蛋白抗原制备的多抗，保证奥叠检测结果是阳性。技术服务实行分步报价，按节点收费，为客户节约成本。
鼠单克隆抗体制备:
客户可根据项目实际需求情况灵活选择进行，我公司将为您的项目提供专业的建议。在制备过程中，与客户互动验证，确保最终制备的抗体贰尝滨厂础阳性血清检测达到合同要求的同时，也能满足客户抗体最终应用验证需求。技术服务实行分步报价，按节点收费，为客户节约成本。
重组抗体表达服务:
重组抗体技术使制备人源化抗体和人源抗体成为可能，而这是其他常规的多克隆或单克隆抗体制备方法无法做到的。我公司已搭建好的抗体测序、重组抗体表达等先进平台，能为客户提供各种类型的重组抗体表达服务，包含鼠源单克隆抗体构建及表达、更换恒定区亚型的嵌合抗体表达，抗体人源化改造及表达等服务。
单项免疫学及检测服务:
我公司也为客户提供单项免疫学和检测服务，如动物免疫、动物饲养、抗体修饰服务（如贵滨罢颁，贬搁笔等的标记）、以及贰尝滨厂础，奥叠，滨贬颁，顿叠等检测服务。
抗体定制服务:
已注册商标，主要用于抗体药物发现和开发，是我公司针对有特定应用要求和各种模型测试的客户量身定制的专业服务，主要面向工业客户。
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