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角质细胞生长因子调节蛋白2抗体
产物名称 | 英文名称 | 货号 |
角质细胞生长因子调节蛋白2抗体 | KRG2/DDX11 | GOY-01K2169 |
商品属性：
英文名称: KRG2/DDX11
中文名:角质细胞生长因子调节蛋白2抗体
别 名；CHL1; CHL1
related helicase gene 1; CHL1-like helicase homolog; CHL1-related protein 1; CHLR1;
Ddx11; DDX11_HUMAN; DEAD/H (Asp Glu Ala Asp/His) box polypeptide 11; DEAD/H box
protein 11; hCHLR1; Keratinocyte growth factor regulated gene 2 protein;
Keratinocyte growth factor-regulated gene 2 protein; KRG 2; KRG-2; KRG2;
Probable ATP dependent RNA helicase DDX11; Probable ATP-dependent RNA helicase
DDX11.
研究领域；细胞生物 细胞周期蛋白 细胞分化 b-淋巴细胞 表观遗传学
抗体来源；Rabbit
克隆类型；Polyclonal
交叉反应；Human,
Mouse, Rat,
产物应用；WB=1:500-2000
ELISA=1:5000-10000 IHC-P=1:100-500 （石蜡切片需做抗原修复）
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理论分子量；108kDa
细胞定位；细胞核
性 状；Liquid
浓 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human KRG2/DDX11: 251-350/970
亚 型；IgG
纯化方法；affinity
purified by Protein A
缓 冲 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
注意事项；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
产物介绍:
DEAD box proteins, characterized by the conserved
motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated
in a number of cellular processes involving alteration of RNA secondary
structure such as translation initiation, nuclear and mitochondrial splicing,
and ribosome and spliceosome assembly. Based on their distribution patterns,
some members of this family are believed to be involved in embryogenesis,
spermatogenesis, and cellular growth and division. This gene encodes a DEAD
box protein, which is an enzyme that possesses both ATPase and DNA helicase
activities. This gene is a homolog of the yeast CHL1 gene, and may function
to maintain chromosome transmission fidelity and genome stability.
Alternative splicing results in multiple transcript variants encoding
distinct isoforms. [provided by RefSeq, Jul 2008] DNA-dependent ATPase and ATP-dependent DNA
helicase that participates in various functions in genomic stability,
including DNA replication, DNA repair and heterochromatin organization as
well as in ribosomal RNA synthesis. Its double-stranded DNA helicase activity
requires either a minimal 5-single-stranded tail length of approximately 15
nt (flap substrates) or 10 nt length single-stranded gapped DNA substrates of
a partial duplex DNA structure for helicase loading and translocation along
DNA in a 5 to 3 direction . The helicase activity is capable of displacing
duplex regions up to 100 bp, which can be extended up to 500 bp by the
replication protein A (RPA) or the cohesion CTF18-replication factor C
(Ctf18-RFC) complex activities . Shows also ATPase- and helicase activities
on substrates that mimic key DNA intermediates of replication, repair and
homologous recombination reactions, including forked duplex, anti-parallel
G-quadruplex and three-stranded D-loop DNA molecules. Plays a role in DNA
double-strand break (DSB) repair at the DNA replication fork during DNA
replication recovery from DNA damage. Recruited with TIMELESS factor upon
DNA-replication stress response at DNA replication fork to preserve
replication fork progression, and hence ensure DNA replication fidelity.
Cooperates also with TIMELESS factor during DNA replication to regulate
proper sister chromatid cohesion and mitotic chromosome segregation.
Stimulates 5-single-stranded DNA flap endonuclease activity of FEN1 in an
ATP- and helicase-independent manner; and hence it may contribute in Okazaki
fragment processing at DNA replication fork during lagging strand DNA
synthesis. Its ability to function at DNA replication fork is modulated by
its binding to long non-coding RNA (lncRNA) cohesion regulator non-coding RNA
DDX11-AS1/CONCR, which is able to increase both DDX11 ATPase activity and
binding to DNA replicating regions. Plays also a role in heterochromatin
organization. Involved in rRNA transcription activation through binding to
active hypomethylated rDNA gene loci by recruiting UBTF and the RNA
polymerase Pol I transcriptional machinery. Plays a role in embryonic
development and prevention of aneuploidy (By similarity). Involved in
melanoma cell proliferation and survival. Associates with chromatin at DNA
replication fork regions. Binds to single- and double-stranded DNAs. |
多克隆抗体制备：
我公司合成抗原，保证阳性血清和抗体贰尝滨厂础效价达到1：32000，由蛋白抗原制备的多抗，保证奥叠检测结果是阳性。技术服务实行分步报价，按节点收费，为客户节约成本。
鼠单克隆抗体制备:
客户可根据项目实际需求情况灵活选择进行，我公司将为您的项目提供专业的建议。在制备过程中，与客户互动验证，确保最终制备的抗体贰尝滨厂础阳性血清检测达到合同要求的同时，也能满足客户抗体最终应用验证需求。技术服务实行分步报价，按节点收费，为客户节约成本。
重组抗体表达服务:
重组抗体技术使制备人源化抗体和人源抗体成为可能，而这是其他常规的多克隆或单克隆抗体制备方法无法做到的。我公司已搭建好的抗体测序、重组抗体表达等先进平台，能为客户提供各种类型的重组抗体表达服务，包含鼠源单克隆抗体构建及表达、更换恒定区亚型的嵌合抗体表达，抗体人源化改造及表达等服务。
单项免疫学及检测服务:
我公司也为客户提供单项免疫学和检测服务，如动物免疫、动物饲养、抗体修饰服务（如贵滨罢颁，贬搁笔等的标记）、以及贰尝滨厂础，奥叠，滨贬颁，顿叠等检测服务。
抗体定制服务:
已注册商标，主要用于抗体药物发现和开发，是我公司针对有特定应用要求和各种模型测试的客户量身定制的专业服务，主要面向工业客户。
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